New polyanhydrides derived from C12,C13,C14,C15 dibasic acid: synthesis and characterization

Poly(dodecanedioic acid-tetradecandioic acid) (P(DDDA-TA)) copolymers and poly(brassylic acid-pentadecandioic acid) (P(BA-PA)) copolymers have been prepared by melt polycondensation of the corresponding mixed anhydride prepolymers derived from dodecanedioic acid, brassylic acid, tetradecandioic acid and pentadecandioic acid. The copolymers were characterized by FT-IR, gel permeation chromatography (GPC), differential scanning calorimetry (DSC), wide angle X-ray powder-diffraction, and thermal gravimetric analysis (TGA). In vitro studies showed that all the copolymers are degradable in phosphate buffer at 37 °C. The release profiles of hydrophilic model drug, ciprofloxcin hydrochloride, from the copolymers, follows first order release kinetics. All the preliminary results suggested that the copolymer might be potentially used as drug delivery devices.