Title of article :
BOLD fMRI mapping of brain responses to nociceptive stimuli in rats under ketamine anesthesia
Author/Authors :
Shih، نويسنده , , Yen-Yu I. and Chang، نويسنده , , Chen and Chen، نويسنده , , Jyh-Cheng and Jaw، نويسنده , , Fu-Shan، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
6
From page :
953
To page :
958
Abstract :
Ketamine is one of the most commonly used anesthetics, but its effects on nociceptive responses are not clearly defined. This study used blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to hemodynamically map responses to formalin stimuli under ketamine anesthesia. All imaging was performed on a 4.7-T fMRI system. During dynamic image acquisition, formalin was injected into the rat hindpaw as a painful stimulant. Correlation coefficients were calculated, and each image was registered and fused with the corresponding rat brain atlas so as to avoid inaccuracies arising from manual definition of the brain area and to achieve atlas-based normalization among subjects. Formalin injections were found to increase BOLD signals in the cingulate cortex, sensory-motor cortices, insular cortex, striatum, nucleus accumbens, medial thalamus, ventrolateral thalamic group, and hippocampus. Moreover, in contrast to previous pain investigations, the frontal subcortical regions were strongly activated in ketamine-anesthetized rats.
Keywords :
Rat , pain , Ketamine , Formalin , FMRI
Journal title :
Medical Engineering and Physics
Serial Year :
2008
Journal title :
Medical Engineering and Physics
Record number :
1730183
Link To Document :
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