Author/Authors :
Halliday، نويسنده , , I. and Atherton، نويسنده , , M. and Care، نويسنده , , C.M. and Collins، نويسنده , , M.W. and Evans، نويسنده , , D. and Evans، نويسنده , , P.C. and Hose، نويسنده , , D.R. and Khir، نويسنده , , A.W. and Kِnig، نويسنده , , C.S. and Krams، نويسنده , , R. G. Lawford، نويسنده , , P.V. and Lishchuk، نويسنده , , S.V. and Pontrelli، نويسنده , , G. and Ridger، نويسنده , , Meredith V. and Spencer، نويسنده , , T.J. and Ventikos، نويسنده , , Y. and Walker، نويسنده , , D.C. and Watton، نويسنده , , P.N.، نويسنده ,
Abstract :
We discuss, from the perspective of basic science, the physical and biological processes which underlie atherosclerotic (plaque) initiation at the vascular endothelium, identifying the widely separated spatial and temporal scales which participate. We draw on current, related models of vessel wall evolution, paying particular attention to the role of particulate flow (blood is not a continuum fluid), and proceed to propose, then validate all the key components in a multiply-coupled, multi-scale modeling strategy (in qualitative terms only, note). Eventually, this strategy should lead to a quantitative, patient-specific understanding of the coupling between particulate flow and the endothelial state.
Keywords :
microcirculation , Wall Shear Stress , Glycocalyx , endothelium , multi-scale
