Design and validation of a cadaveric knee joint loading device compatible with magnetic resonance imaging and computed tomography

AbstractPurpose and validation of a magnetic resonance and computed tomography compatible device capable of applying physiologically relevant muscle forces to cadaveric knee joints with high levels of repeatability and reproducibility. s ability and reproducibility were assessed with two porcine stifle joints. Load was applied to joints at full extension, five and 15 degrees of flexion through two cables simulating the lines of action of the quadriceps and hamstrings muscles. Five repeatability and five reproducibility trials were performed at each flexion angle. Standard deviations (SDs) of joint angle and load were recorded. s peatability, the maximum SDs for joint angle were 1.26° (flexion), 1.54° (ab/adduction) and 0.90° (in/external rotation). The maximum SDs for joint load were 4.60 N (anterior/posterior), 7.36 N (medial/lateral), and 42.6 N (axial). For reproducibility, the maximum SDs for joint angle were 0.84° (flexion), 0.66° (ab/adduction) and 0.92° (in/external rotation). The maximum SDs for joint load were 6.40 N (anterior/posterior), 11.7 N (medial/lateral), and 39.7 N (axial). sions evel of repeatability and reproducibility is within intra-subject variability of measured gait kinematics. Therefore, this device is considered to be an effective tool for in vitro testing of knee soft tissue repair.