Interaction of poly(N-acryloyl-amino acids) with saccharides in aqueous media

The interaction of a series of poly(N-acryloyl-amino acids) (pAXaa) with saccharides has been investigated by 1H NMR. 1H NMR for methyl-β-d-galactopyranoside (MβGal) in the presence of pAXaa indicated that hydrophobic interaction or hydrogen bonding was not considerable in the interaction of the polymers with MβGal in aqueous media whereas CH–π interaction was relatively important. 1H NMR for several saccharides in the presence of poly(N-acryloyltryptophan) (pATrp) indicated that pATrp interacted more strongly with the β-anomers than with the α-anomers presumably because of the triple CH–π interactions of the three axial protons in the β-anomers. In the interaction of pATrp with MβGal, MβGal interacted with two or more Trp residues because Trp residues were localized on the polymer chain.