Author/Authors :
Xu، نويسنده , , Qingling and Zhu، نويسنده , , Litao and Yu، نويسنده , , Minghui and Feng، نويسنده , , Fude and An، نويسنده , , Lingling and Xing، نويسنده , , Chengfen and Wang، نويسنده , , Shu، نويسنده ,
Abstract :
Nuclear magnetic resonance imaging (MRI) has become a powerful technique in clinical diagnostics. In this work, a new MRI contrast agent by covalently linking Gd(III) chelates to the side chain of conjugated polymer (PF–Gd) is synthesized by Suzuki cross-coupling reaction. The PF–Gd exhibits a higher relaxivity and a pronounced enhancement in contrast than that of (NMG)2–Gd–DTPA widely used for clinical diagnosis. This work should be feasible to potentially lead to a new class of imaging contrast agents.
