Author/Authors :
Alassane Wélé، نويسنده , , Mamadou and Djimdé، نويسنده , , Abdoulaye A. and Guindo، نويسنده , , Aldiouma and Beavogui، نويسنده , , Abdoul H. and Traoré، نويسنده , , Isaac Z. and Sadou، نويسنده , , Aboubacar and Blaise، نويسنده , , Dackouo and Diallo، نويسنده , , Dapa A. and Wellems، نويسنده , , Thomas E. and Doumbo، نويسنده , , Ogobara K.، نويسنده ,
Abstract :
We investigated PfCRT 76T mutation in severe and non-severe malaria in Southern Mali. One hundred and ninety three severe malaria cases were each matched against two non-severe malaria cases. Patients with G6PD deficiency and any known hemoglobin abnormality were excluded. PfCRT 76T was present in 60.8% (n = 386) non-severe malaria cases and in 77.2% (n = 193) severe malaria cases (p < 0.0001). In children 5 years or younger, these proportions were 62.9% (n = 294) vs. 73.5% (n = 147), respectively (p < 0.01). PfCRT 76T was therefore associated with malaria severity in this setting of Mali.
Keywords :
Severe malaria , Drug resistance , Non-severe malaria , PfCRT 76T
