Title of article :
Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax
Author/Authors :
Gustavo Capatti and Storti-Melo، نويسنده , , Luciane Moreno and da Costa، نويسنده , , Daniela Reis and Souza-Neiras، نويسنده , , Wanessa Christina and Cassiano، نويسنده , , Gustavo Capatti and Couto، نويسنده , , Vanja Suely Calvosa D’Almeida and P?voa، نويسنده , , Marinete Marins and Soares، نويسنده , , Irene da Silva and de Carvalho، نويسنده , , Luzia Helena and Arevalo-Herrera، نويسنده , , Myrian and Herrera، نويسنده , , S?crates and Rossit، نويسنده , , Andrea Regina Baptista and Cordeiro، نويسنده , , José Antonio and de Mattos، نويسنده , , Luiz Carlos and Machado، نويسنده , , Ricardo Luiz Dantas Machado، نويسنده ,
Abstract :
We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HLA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the HLA-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria.
