Author/Authors :
Park، نويسنده , , Duk-Woo and Kim، نويسنده , , Young-Hak and Yun، نويسنده , , Sung-Cheol and Kang، نويسنده , , Soo-Jin and Lee، نويسنده , , Seungwhan and Lee، نويسنده , , Cheol Whan and Park، نويسنده , , Seong-Wook and Seong، نويسنده , , In-Whan and Lee، نويسنده , , Jae-Hwan and Tahk، نويسنده , , Seung-Jea and Jeong، نويسنده , , Myung-Ho and Jang، نويسنده , , Yangsoo and Cheong، نويسنده , , Sang-Sig and Yang، نويسنده , , Joo-Young and Lim، نويسنده , , Do-Sun and Seung، نويسنده , , Ki-Bae and Chae، نويسنده , , Jei-Keon and Hur، نويسنده , , Seung-Ho and Lee، نويسنده , , Sang-Gon and Yoon، نويسنده , , Junghan and Lee، نويسنده , , Nae-Hee and Choi، نويسنده , , Young-Jin and Kim، نويسنده , , Hyunsook and Kim، نويسنده , , Kee-Sik and Kim، نويسنده , , Hyo-Soo and Hong، نويسنده , , Taeg-Jong and Park، نويسنده , , Hun-Sik and Park، نويسنده , , Seung-Jung، نويسنده ,
Abstract :
Objectives
m of this study was to evaluate the relative efficacy and safety of zotarolimus-eluting stents (ZES) in comparison with the established and widely used sirolimus- (SES) and paclitaxel-eluting stents (PES) in routine clinical practice.
ound
r ZES might provide similar clinical and angiographic outcomes in a broad spectrum of patients compared with SES or PES is undetermined.
s
formed a single-blind, multicenter, prospectively randomized trial to compare ZES with SES and PES in 2,645 patients undergoing percutaneous coronary intervention. The primary end point was a composite of major adverse cardiac events (MACE) (death, myocardial infarction, and ischemia-driven target vessel revascularization) at 12 months. A noninferiority comparison (ZES vs. SES) and a superiority comparison (ZES vs. PES) were performed for the primary end point.
s
ne clinical and angiographic characteristics were similar in the 3 groups. At 12 months, the ZES group showed noninferior rates of MACE compared with the SES group (10.2% vs. 8.3%, p for noninferiority = 0.01, p for superiority = 0.17) and significantly fewer MACE than the PES group (10.2% vs. 14.1%, p for superiority = 0.01). The incidence of death or myocardial infarction was similar among the groups (ZES vs. SES vs. PES, 5.8% vs. 6.9% vs. 7.6%, respectively, p = 0.31). The incidence of stent thrombosis was significantly lower in the SES group (ZES vs. SES vs. PES, 0.7% vs. 0% vs. 0.8%, respectively, p = 0.02).
sions
s large-scale, practical randomized trial, the use of ZES resulted in similar rates of MACE compared with SES and in fewer MACE compared with PES at 12 months. (Comparison of the Efficacy and the Safety of Zotarolimus-Eluting Stent Versus Sirolimus-Eluting Stent and PacliTaxel-Eluting Stent for Coronary Lesions; NCT00418067)
