Author/Authors :
Thian، نويسنده , , E.S. and Ahmad، نويسنده , , Z. and Huang، نويسنده , , J. and Edirisinghe، نويسنده , , M.J. and Jayasinghe، نويسنده , , S.N. and Ireland، نويسنده , , D.C. and Brooks، نويسنده , , R.A. and Rushton، نويسنده , , N. and Bonfield، نويسنده , , W. M. Best، نويسنده , , S.M.، نويسنده ,
Abstract :
A new deposition method is presented, based on electrospraying, that can build bioceramic structures with desirable surface properties. This technology allows nanoapatite crystals, including hydroxyapatite (nHA), carbonate-substituted HA (nCHA) and silicon-substituted HA (nSiHA), to be electrosprayed on glass substrates. Human osteoblast cells cultured on nSiHA showed enhanced cell attachment, proliferation and protein expression, namely alkaline phosphatase, type 1 collagen and osteocalcin, as compared to nHA and nCHA. The modification of nanoapatite by the addition of silicon into the HA lattice structure renders the electrosprayed surface more hydrophilic and electronegatively charged.
Keywords :
Osteoblasts , Silicon , CARBONATE , Nanoapatites , Electrospraying
