Author/Authors :
Zendehdel، Mojgan نويسنده 1Department of Chemistry, Faculty of Science, Arak University, Arak 38156-8-8349, Iran , , Cruciani، Giuseppe نويسنده Department of Physics and Earth Sciences, University of Ferrara Via Saragat 1, Ferrara I-44100, Italy , , Sahra Kar، Forozan نويسنده 1Department of Chemistry, Faculty of Science, Arak University, Arak 38156-8-8349, Iran , , Barati، Abolfazl نويسنده ,
Abstract :
Recently, hybrid materials using poly ethylene glycol and porous nanocrystals have been developed for drug
release. In this study, a series of poly ethylene glycol (PEG)/NaY zeolite and PEG/MCM-41 nanocomposites get
synthesized. These materials are characterized using FT-IR spectroscopy, XRD, TGA and SEM. After loading the
metronidazole onto these nanocomposites, the release of Metronidazole was studied in two kinds of release fluids
simulating body fluid KH2PO4-Na2HPO4 buffer (pH = 7.4) and gastric fluid (HCl aqueous solution, pH = 1.5) while
controlling the time, pH values, and temperature using UV–vis. Results showed that these nanocomposites have
further release related to NaY, MCM-41 and the order of release in two pH solutions was PEG/NaY > PEG/MCM-41 >
NaY > MCM-41. The behavior of drug release in these nanocomposites is probably due to hydrogen bonding
interactions between drug and the hydroxyl group on the composite framework.
