Author/Authors :
Pensabene، نويسنده , , Virginia and Taccola، نويسنده , , Silvia and Ricotti، نويسنده , , Leonardo and Ciofani، نويسنده , , Gianni and Menciassi، نويسنده , , Arianna and Perut، نويسنده , , Francesca and Salerno، نويسنده , , Manuela and Dario، نويسنده , , Paolo and Baldini، نويسنده , , Nicola، نويسنده ,
Abstract :
Ultrathin films (also called nanofilms) are two-dimensional (2-D) polymeric structures with potential application in biology, biotechnology, cosmetics and tissue engineering. Since they can be handled in liquid form with micropipettes or tweezers they have been proposed as flexible systems for cell adhesion and proliferation. In particular, with the aim of designing a novel patch for bone or tendon repair and healing, in this work the biocompatibility, adhesion and proliferation activity of Saos-2, MRC-5 and human and rat mesenchymal stem cells on poly(lactic acid) nanofilms were evaluated. The nanofilms did not impair the growth and differentiation of osteoblasts and chondrocytes. Moreover, nanofilm adhesion to rabbit joints was evident under ex vivo conditions.
Keywords :
mesenchymal stem cells , Bone repair , Poly (lactic) acid , Ultrathin nanofilm , Cell differentiation
