Title of article
Flexible polymeric ultrathin film for mesenchymal stem cell differentiation
Author/Authors
Pensabene، نويسنده , , Virginia and Taccola، نويسنده , , Silvia and Ricotti، نويسنده , , Leonardo and Ciofani، نويسنده , , Gianni and Menciassi، نويسنده , , Arianna and Perut، نويسنده , , Francesca and Salerno، نويسنده , , Manuela and Dario، نويسنده , , Paolo and Baldini، نويسنده , , Nicola، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
9
From page
2883
To page
2891
Abstract
Ultrathin films (also called nanofilms) are two-dimensional (2-D) polymeric structures with potential application in biology, biotechnology, cosmetics and tissue engineering. Since they can be handled in liquid form with micropipettes or tweezers they have been proposed as flexible systems for cell adhesion and proliferation. In particular, with the aim of designing a novel patch for bone or tendon repair and healing, in this work the biocompatibility, adhesion and proliferation activity of Saos-2, MRC-5 and human and rat mesenchymal stem cells on poly(lactic acid) nanofilms were evaluated. The nanofilms did not impair the growth and differentiation of osteoblasts and chondrocytes. Moreover, nanofilm adhesion to rabbit joints was evident under ex vivo conditions.
Keywords
mesenchymal stem cells , Bone repair , Poly (lactic) acid , Ultrathin nanofilm , Cell differentiation
Journal title
Acta Biomaterialia
Serial Year
2011
Journal title
Acta Biomaterialia
Record number
1755129
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