Author/Authors :
Gong، نويسنده , , Shi-qiang and Niu، نويسنده , , Li-na and Kemp، نويسنده , , Lisa K. and Yiu، نويسنده , , Cynthia K.Y. and Ryou، نويسنده , , Heonjune and Qi، نويسنده , , Yi-pin and Blizzard، نويسنده , , John D. and Nikonov، نويسنده , , Sergey and Brackett، نويسنده , , Martha G. and Messer، نويسنده , , Regina L.W. and Wu، نويسنده , , Christine D. and Mao، نويسنده , , Jing and Bryan Brister، نويسنده , , L. and Rueggeberg، نويسنده , , Frederick A. and Arola، نويسنده , , Dwayne D. and Pashley، نويسنده , , David H. and Tay، نويسنده , , Franklin R.، نويسنده ,
Abstract :
The design of antimicrobial polymers to address healthcare issues and minimize environmental problems is an important endeavor with both fundamental and practical implications. Quaternary ammonium silane-functionalized methacrylate (QAMS) represents an example of antimicrobial macromonomers synthesized by a sol–gel chemical route; these compounds possess flexible Si–O–Si bonds. In present work, a partially hydrolyzed QAMS co-polymerized with 2,2-[4(2-hydroxy 3-methacryloxypropoxy)-phenyl]propane is introduced. This methacrylate resin was shown to possess desirable mechanical properties with both a high degree of conversion and minimal polymerization shrinkage. The kill-on-contact microbiocidal activities of this resin were demonstrated using single-species biofilms of Streptococcus mutans (ATCC 36558), Actinomyces naeslundii (ATCC 12104) and Candida albicans (ATCC 90028). Improved mechanical properties after hydration provided the proof-of-concept that QAMS-incorporated resin exhibits self-repair potential via water-induced condensation of organic modified silicate (ormosil) phases within the polymerized resin matrix.
Keywords :
Organic modified silicate , Sol–gel technique , Self-repair , Antimicrobial , Quaternary ammonium
