Title of article :
Bioactive self-assembled peptide nanofibers for corneal stroma regeneration
Author/Authors :
Uzunalli، نويسنده , , G. and Soran، نويسنده , , Z. and Erkal، نويسنده , , T.S. and Dagdas، نويسنده , , Y.S. and Dinc، نويسنده , , E. and Hondur، نويسنده , , A.M. and Bilgihan، نويسنده , , K. and Aydin، نويسنده , , Ayse B. and Guler، نويسنده , , M.O. and Tekinay، نويسنده , , A.B.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Pages :
11
From page :
1156
To page :
1166
Abstract :
Defects in the corneal stroma caused by trauma or diseases such as macular corneal dystrophy and keratoconus can be detrimental for vision. Development of therapeutic methods to enhance corneal regeneration is essential for treatment of these defects. This paper describes a bioactive peptide nanofiber scaffold system for corneal tissue regeneration. These nanofibers are formed by self-assembling peptide amphiphile molecules containing laminin and fibronectin inspired sequences. Human corneal keratocyte cells cultured on laminin-mimetic peptide nanofibers retained their characteristic morphology, and their proliferation was enhanced compared with cells cultured on fibronectin-mimetic nanofibers. When these nanofibers were used for damaged rabbit corneas, laminin-mimetic peptide nanofibers increased keratocyte migration and supported stroma regeneration. These results suggest that laminin-mimetic peptide nanofibers provide a promising injectable, synthetic scaffold system for cornea stroma regeneration.
Keywords :
Corneal stroma regeneration , YIGSR , RGD , Peptide amphiphile , SELF-ASSEMBLY
Journal title :
Acta Biomaterialia
Serial Year :
2014
Journal title :
Acta Biomaterialia
Record number :
1757883
Link To Document :
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