Title of article :
Contributions of human tissue analysis to understanding the mechanisms of loosening and osteolysis in total hip replacement
Author/Authors :
Gallo، نويسنده , , Jiri and Vaculova، نويسنده , , Jana and Goodman، نويسنده , , Stuart B. and Konttinen، نويسنده , , Yrjِ T. and Thyssen، نويسنده , , Jacob P.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Pages :
13
From page :
2354
To page :
2366
Abstract :
Aseptic loosening and osteolysis are the most frequent late complications of total hip arthroplasty (THA) leading to revision of the prosthesis. This review aims to demonstrate how histopathological studies contribute to our understanding of the mechanisms of aseptic loosening/osteolysis development. Only studies analysing periprosthetic tissues retrieved from failed implants in humans were included. Data from 101 studies (5532 patients with failure of THA implants) published in English or German between 1974 and 2013 were included. “Control” samples were reported in 45 of the 101 studies. The most frequently examined tissues were the bone–implant interface membrane and pseudosynovial tissues. Histopathological studies contribute importantly to determination of key cell populations underlying the biological mechanisms of aseptic loosening and osteolysis. The studies demonstrated the key molecules of the host response at the protein level (chemokines, cytokines, nitric oxide metabolites, metalloproteinases). However, these studies also have important limitations. Tissues harvested at revision surgery reflect specifically end-stage failure and may not adequately reveal the evolution of pathophysiological events that lead to prosthetic loosening and osteolysis. One possible solution is to examine tissues harvested from stable total hip arthroplasties that have been revised at various time periods due to dislocation or periprosthetic fracture in multicenter studies.
Keywords :
Immunostaining , Tissue analysis , Aseptic loosening , osteolysis , Total hip
Journal title :
Acta Biomaterialia
Serial Year :
2014
Journal title :
Acta Biomaterialia
Record number :
1758086
Link To Document :
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