Title of article :
Microdialysis and drug delivery to the eye
Author/Authors :
Rittenhouse، نويسنده , , Kay D and Pollack، نويسنده , , Gary M، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
13
From page :
229
To page :
241
Abstract :
The eye presents unique challenges in both the development of tools for elucidating drug disposition as well as for the development of modes of drug delivery for treatment of ocular diseases. In this paper, we present a discussion of the anatomical and physiological characteristics and limitations present in the eye for microdialysis sampling of endogenous substrates and xenobiotics. To date, over twenty papers describing microdialysis approaches for assessment of ocular drug delivery and endogenous substrate characterization have been published. Although the majority of papers describe sampling of vitreous humor, recent efforts have been directed towards ocular anterior segment sampling using microdialysis. With this approach, an appreciable reduction in animal use has been realized. In addition, simultaneous examination of administered drug and endogenous substrates modulated by the drug is possible with this approach, facilitating construction of ocular pharmacokinetic/pharmacodynamic relationships through use of relevant surrogate markers.
Keywords :
Blood–aqueous barrier , Pharmacodynamics , Vitreous humor , aqueous humor , Pharmacokinetics , Ocular drug delivery
Journal title :
Advanced Drug Delivery Reviews
Serial Year :
2000
Journal title :
Advanced Drug Delivery Reviews
Record number :
1760589
Link To Document :
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