Title of article
Mitochondrial DNA metabolism targeting drugs
Author/Authors
Rowe، نويسنده , , Thomas C and Weissig، نويسنده , , Volkmar and Lawrence، نويسنده , , Jeffrey W، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
13
From page
175
To page
187
Abstract
Numerous drugs are known to deplete mitochondrial DNA (mtDNA) from mammalian cells. These include DNA polymerase γ and type II topoisomerase inhibitors, lipophilic cationic compounds, and DNA intercalating and non intercalating agents. The effects of these drugs on mtDNA metabolism will be discussed and potential mechanisms underlying their depletion of mtDNA presented.
Keywords
Viral , Lipophilic , intercalator , Dideoxynucleoside , Mitochondria , topoisomerase , polyamine , REPLICATION , Inhibitor , polymerase
Journal title
Advanced Drug Delivery Reviews
Serial Year
2001
Journal title
Advanced Drug Delivery Reviews
Record number
1760711
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