Accuracy of a recently proposed method for estimating creatinine clearance in elderly debilitated patients

The present study was conducted to evaluate accuracy of a recently proposed method for estimating creatinine clearance (CLcr, ml/min) from actual body weight (ABW, kg), serum creatinine (Scr, μmol/l), and serum albumin (Alb, g/l) in elderly patients with muscle atrophy (the debilitated elderly). The recent method (Alb method) is CLcr=(1.6*Alb+28)*(ABW/Scr) for males and CLcr=(1.1*Alb+25)*(ABW/Scr) for females. In 46 debilitated elderly inpatients (64–96 years of age), CLcr was actually measured, and it was estimated by Cockcroft and Gaultʹs method (C–G method), the C–G method corrected by lean body weight (LBW method), and the Alb method. The accuracy was accessed by mean prediction error (ME, ml/min) and mean squared error (MSE, [ml/min]2). The C–G method yielded ME=7.39 and MSE=448.3, the LBW method gave ME=6.33 and MSE=385.9, and the Alb method provided ME=3.66 and MSE=196.1. The Alb method was found the most accurate in the debilitated elderly.