Title of article
Age-related changes in plasma lipid peroxidation and antioxidant system in humans and rats
Author/Authors
Mehmetcik، نويسنده , , G and ?zdemirler، نويسنده , , KANBAGLI، OZNUR نويسنده , , ? and Toker، نويسنده , , G and Uysal، نويسنده , , M، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
6
From page
305
To page
310
Abstract
This study was carried out on young (20–35 years) and old (60–85 years) men and rats (6 vs 22 months) to investigate the effect of aging on plasma lipid peroxidation and the antioxidant system. Plasma polyunsaturated fatty acid (PUFA), total fatty acid (TFA) and malondialdehyde (MDA) levels increased in aged humans and rats compared with young groups. However, plasma MDA/TFA ratios did not increase in aged humans and rats. Plasma vitamin E/TFA, and total thiol content were found to decrease both in aged humans and rats. Plasma antioxidant activity (AOA) decreased only in aged rats. In addition, the susceptibility of VLDL+LDL, apolipoprotein B containing lipoproteins to copper-induced peroxidation increased with aging. It is concluded that aging is associated with some variations in plasma oxidant–antioxidant balance.
Keywords
Lipid peroxidation , Apo-B containing lipoproteins , PLASMA , Antioxidant system , aging
Journal title
Archives of Gerontology and Geriatrics
Serial Year
1997
Journal title
Archives of Gerontology and Geriatrics
Record number
1761427
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