Polymer assemblies for controlled delivery of bioactive molecules from surfaces

Localized delivery of bioactive compounds from surfaces of biomedical devices affords significant therapeutic benefits, and often relies on the capability of surface coatings to provide spatial and temporal control over release rate. The layer-by-layer technique presents a unique means to construct surface coatings that can conform to a variety of biomaterial surfaces and serve as matrices enabling controlled delivery of bioactive molecules from surfaces. The versatility of layer-by-layer assembly enables construction of surface coatings of diverse chemistry and internal architecture with controlled release properties. This review focuses on recent developments in constructing such layered matrices using linear polymers, polymer nanoparticles and block copolymer micelles, including micelles with stimuli-responsive cores, as film building blocks and in controlling release rate of therapeutics from these matrices via degradation, application of pH, ionic strength, temperature, light, electric field and chemical or biological stimuli. Challenges and opportunities associated with fabrication of stratified multilayer films capable of multi-stage delivery of multiple drugs are also discussed.