Title of article
Recent advances in predicting skin permeability of hydrophilic solutes
Author/Authors
Chen، نويسنده , , Longjian and Han، نويسنده , , Lujia and Lian، نويسنده , , Guoping، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
11
From page
295
To page
305
Abstract
Understanding the permeation of hydrophilic molecules is of relevance to many applications including transdermal drug delivery, skin care as well as risk assessment of occupational, environmental, or consumer exposure. This paper reviews recent advances in modeling skin permeability of hydrophilic solutes, including quantitative structure–permeability relationships (QSPR) and mechanistic models. A dataset of measured human skin permeability of hydrophilic and low hydrophobic solutes has been compiled. Generally statistically derived QSPR models under-estimate skin permeability of hydrophilic solutes. On the other hand, including additional aqueous pathway is necessary for mechanistic models to improve the prediction of skin permeability of hydrophilic solutes, especially for highly hydrophilic solutes. A consensus yet has to be reached as to how the aqueous pathway should be modeled. Nevertheless it is shown that the contribution of aqueous pathway can constitute to more than 95% of the overall skin permeability. Finally, future prospects and needs in improving the prediction of skin permeability of hydrophilic solutes are discussed.
Keywords
Aqueous porous pathway , Brick-and-mortar , Quantitative structure–permeability relationships , Skin permeability , Hydrophilic , Stratum corneum , Transdermal permeation
Journal title
Advanced Drug Delivery Reviews
Serial Year
2013
Journal title
Advanced Drug Delivery Reviews
Record number
1763645
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