• Title of article

    Recent advances in predicting skin permeability of hydrophilic solutes

  • Author/Authors

    Chen، نويسنده , , Longjian and Han، نويسنده , , Lujia and Lian، نويسنده , , Guoping، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2013
  • Pages
    11
  • From page
    295
  • To page
    305
  • Abstract
    Understanding the permeation of hydrophilic molecules is of relevance to many applications including transdermal drug delivery, skin care as well as risk assessment of occupational, environmental, or consumer exposure. This paper reviews recent advances in modeling skin permeability of hydrophilic solutes, including quantitative structure–permeability relationships (QSPR) and mechanistic models. A dataset of measured human skin permeability of hydrophilic and low hydrophobic solutes has been compiled. Generally statistically derived QSPR models under-estimate skin permeability of hydrophilic solutes. On the other hand, including additional aqueous pathway is necessary for mechanistic models to improve the prediction of skin permeability of hydrophilic solutes, especially for highly hydrophilic solutes. A consensus yet has to be reached as to how the aqueous pathway should be modeled. Nevertheless it is shown that the contribution of aqueous pathway can constitute to more than 95% of the overall skin permeability. Finally, future prospects and needs in improving the prediction of skin permeability of hydrophilic solutes are discussed.
  • Keywords
    Aqueous porous pathway , Brick-and-mortar , Quantitative structure–permeability relationships , Skin permeability , Hydrophilic , Stratum corneum , Transdermal permeation
  • Journal title
    Advanced Drug Delivery Reviews
  • Serial Year
    2013
  • Journal title
    Advanced Drug Delivery Reviews
  • Record number

    1763645