Title of article
TYMS, MTHFR, p53 and MDR1 gene polymorphisms in breast cancer patients treated with adjuvant therapy
Author/Authors
Henrيquez-Hernلndez، نويسنده , , Luis Alberto and Pérez، نويسنده , , Leandro Fernلndez and Hernلndez، نويسنده , , Ana Gonzلlez and de Leَn، نويسنده , , Antonio Cabrera and Dيaz-Chico، نويسنده , , Bonifacio and Rosales، نويسنده , , A. Murias، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
4
From page
490
To page
493
Abstract
Purpose: The distribution of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms was investigated in 80 consecutive breast cancer patients treated with adjuvant chemotherapy. Results: Observed allelic frequencies were: TSER, (2) 0.55 and (3) 0.45; MTHFR C677T, (C) 0.65 and (T) 0.35; p53 Arg72Pro, (Arg) 0.76 and (Pro) 0.24; MDR1 C3435T, (C) 0.51 and (T) 0.49. MTHFR C677T was found to be a strong predictor of the presence of multifocal tumour (odds ratio, 4.1; 95% CI, 1.1–15.7; P = 0.035). Conclusion: Our data indicate that breast cancer patients with the C/C variant may present multifocal tumour most frequently.
Keywords
risk factors , MTHFR , breast cancer , Multifocal tumour , PCR-RFLP , Polymorphism , adjuvant chemotherapy
Journal title
Cancer Epidemiology
Serial Year
2010
Journal title
Cancer Epidemiology
Record number
1764805
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