Title of article :
Incidence of bone metastases and survival after a diagnosis of bone metastases in breast cancer patients
Author/Authors :
Harries، نويسنده , , M. and Taylor، نويسنده , , A. and Holmberg، نويسنده , , L. and Agbaje، نويسنده , , O. and Garmo، نويسنده , , H. and Kabilan، نويسنده , , S. and Purushotham، نويسنده , , A.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Abstract :
Background: Bone is the most common metastatic site associated with breast cancer. Using a database of women with breast cancer treated at Guyʹs Hospital, London 1976–2006 and followed until end 2010, we determined incidence of and survival after bone metastases. Methods: We calculated cumulative incidence of bone metastases considering death without prior bone metastases as a competing risk. Risk of bone metastases was modelled through Cox-regression. Survival after bone metastases diagnosis was calculated using Kaplan–Meier methodology. Results: Of the 7064 women, 589 (22%) developed bone metastases during 8.4 years (mean). Incidence of bone metastases was significantly higher in younger women, tumour size >5 cm, higher tumour grade, lobular carcinoma and ≥four positive nodes, but was not affected by hormone receptor status. Median survival after bone metastases diagnosis was 2.3 years in women with bone-only metastases compared with <1 year in women with visceral and bone metastases. There was a trend for decreased survival for patients who developed visceral metastases early, and proportionately fewer patients in this group. Interpretation: Incidence of bone metastases has decreased but bone metastases remain a highly relevant clinical problem due to the large number of patients being diagnosed with breast cancer.
Keywords :
breast cancer , Bone metastases , Incidence , Survival
Journal title :
Cancer Epidemiology
Journal title :
Cancer Epidemiology