Title of article
Age-related changes of forkhead transcription factor FOXO1 in the liver of senescence-accelerated mouse SAMP8
Author/Authors
Tomobe، نويسنده , , Koji and Shinozuka، نويسنده , , Tatsuo and Kawashima، نويسنده , , Tsuyoshi and Kawashima-Ohya، نويسنده , , Yoshie and Nomura، نويسنده , , Yasuyuki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
6
From page
417
To page
422
Abstract
SAMP8 exhibits accelerated aging and a short lifespan. Insulin-like growth factor-1 receptor (IGF-1R)/FOXO pathway is associated with aging. Phosphorylation of IGF-1R, Akt, and FOXO1 was found to be increased during aging in the liver of SAMR1 normal agin
Keywords
longevity , Foxo1 , IGF-1R , SAMP8 , Antioxidant enzyme , senescence
Journal title
Archives of Gerontology and Geriatrics
Serial Year
2013
Journal title
Archives of Gerontology and Geriatrics
Record number
1767702
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