Development of a new DNA chip microarray by hydrophobic interaction

We describe here a new approach for an arrangement of many kinds of DNAs on transducers to construct a DNA chip microarray. A high-density array of sensor probes was prepared by randomly distributing a mixture of particles immobilized with various DNAs. A process for immobilization of the DNAs was separated from the assembly of the particles. The particles were arranged on the chip pattern by random fluidic self-assembly using hydrophobic interaction.