Author/Authors :
Alaee، S نويسنده Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz , , Ghaffari Novin، M نويسنده Department of Biology and Anatomical Sciences, Faculty of medicine, Shahid Beheshti University of Medical Sciences, Tehran , , Yeganeh، F نويسنده Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran ,
Abstract :
One of the most important and limiting factors in assisted reproductive technologies (ART) is repeated
implantation failure (RIF). In the process of embryo implantation, appropriate function of the progesterone hormone
through its receptors is critical for establishment of a receptive endometrium. FKBP51 and FKBP52 are two cochaperones of progesterone receptors that participate in the progesterone signaling pathway and endometrial
receptivity. These 51 and 52 KD proteins increase and decrease the affinity of progesterone hormone receptors to
their ligand, respectively. The endometrial tissue of RIF patients might have different patterns of FKBP51 and
FKBP52 gene expression. These molecules can easily be detected and quantified by quantitative reverse
transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemical (IHC) studies. Assessment ofthese
molecules could be a valuable method for evaluationof endometrial receptivity and prediction of the implantation
and pregnancy outcome before beginning a treatment cycle for RIF patients in ART procedures.
