Preparation of pyrazoline nanoparticles with a membrane mixer

In this paper, nanoparticles of 1-phenyl-3-(p-methoxyl-styryl)-5-(p-methoxyl-phenyl)-2-pyrazoline, about 10 nm in mean size, were prepared with a membrane mixer through a solvent displacement process. The effects of the operating modes with or without cycling on the particles, the relationship between the organic compounds hydrophobicity (expressed with the Rekker constants) and particles formation were studied. It seemed that the Rekker constants could be used for the estimation and prediction of particles formation in the preparation of organic particles. The successful control of particles size was attributed to the small droplets size of permeated solution and the relative small hydrophobicity value of the pyrazoline molecule.