Rocuronium Administration in Children During Isoflurane Anesthesia: Neuromuscular Effects

Background me-course of the effect of rocuronium during isoflurane anesthesia in children has rarely been evaluated. Forty-five children, aged 2–14 years, ASA 1, undergoing elective surgery and receiving isoflurane anesthesia, were studied. s ts randomly received a dose of 400, 600, or 800 μg/kg of rocuronium. The first response to the control height (T1:T0) was fitted to time in order to obtain times to onset of action (TOA) including time to 90 (B90) and 99.9% (B100) of relaxation and to spontaneous recovery of 10 (T10), 25 (T25), 50 (T50), 75 (T75), and 90% (T90) of neuromuscular function (NMF). Each time was compared among groups. Linear regression analysis between the TOA or the times to spontaneous recovery of NMF (TSRNMF) and age or weight were also performed. s A were similar among the three groups while TSRNF in children receiving 600 or 800 μg/kg were longer (p <0.05) than children receiving 400 μg/kg. The T10 and T25 were related to age (p = 0.05), whereas T10, T50, T75, and T90 were related to weight (p <0.01). These relationships were stronger in males than females. sions l relaxation was reached in all children receiving 600 or 800 μg/kg of rocuronium. The TSRNMF were mainly related to the weight of the children, and gender affected each relationship. Widely variable responses were observed with all three doses.