Author/Authors :
William C. Black IV، نويسنده , , William C. and Bennett، نويسنده , , Kristine E. and Gorroch?tegui-Escalante، نويسنده , , Norma and Barillas-Mury، نويسنده , , Carolina V. and Fern?ndez-Salas، نويسنده , , Ildefonso and de Lourdes Mu?oz، نويسنده , , Mar??a and Farf?n-Alé، نويسنده , , José A. and Olson، نويسنده , , Ken E. and Beaty، نويسنده , , Barry J.، نويسنده ,
Abstract :
Aedes aegypti is the primary vector of yellow fever (YF) and dengue fever (DF) flaviviruses worldwide. In this review we focus on past and present research on genetic components and environmental factors in Aedes aegypti that appear to control flavivirus transmission. We review genetic relationships among Ae. aegypti populations throughout the world and discuss how variation in vector competence is correlated with overall genetic differences among populations. We describe current research into how genetic and environmental factors jointly affect distribution of vector competence in natural populations. Based on this information, we propose a population genetic model for vector competence and discuss our recent progress in testing this model. We end with a discussion of approaches being taken to identify the genes that may control flavivirus susceptibility in Ae. aegypti.
Keywords :
Aedes aegypti , Vector competence , Flavivirus , population genetics
