Adequate nourishment through total parenteral nutrition treatment may augment immune function in patients with colon cancer

Background jective was to evaluate immune function after total parenteral nutrition (TPN) treatment in colorectal cancer patients. s ere collected from 11 patients with colorectal cancer who received total parenteral nutrition. Healthy medical staff volunteers were used as controls. Delay hypersensitivity skin test with eight agents tested was used before total parenteral nutrition (TPN) treatment. Phytohemagglutinin (PHA)-stimulated lymphocyte proliferation and mononuclear cytokine production (IL-1β, IL-2, IFNγ), serum ICAM-1 and IL-6, and lymphocyte subpopulation including CD4, CD8, and CD4/CD8 ratio were measured before and after TPN treatment. s atient had at least four of seven positive skin tests. After TPN treatment, lymphocyte proliferation increased remarkably (27,450 ± 16,800 vs. 41,738 ± 28,484, p = 0.0168) and showed no significant difference to control group (p = 0.0269). Levels of IL-1β, IL-2, and IFNγ after LPS-stimulation showed no significant difference before and after TPN treatment. Serum ICAM-1 showed a significant difference (388 ± 158 vs. 481 ± 210, p = 0.0023) before and after TPN treatment. IL-6 was significantly different between patient and control groups but not different between patients before and after TPN treatment. sions tudy showed a significant increase of mitogen-stimulated lymphocyte proliferation and intercellular adhesion molecular 1 (ICAM-1) level after TPN supply. Adequate nutrition through TPN may augment immune function.