Title of article :
Impaired Synthesis Is Not the Reason for Decreased Activity of Extracellular Superoxide Dismutase in Patients with Diabetes
Author/Authors :
Ciechanowski، نويسنده , , Kazimierz and K?dzierska، نويسنده , , Karolina and Go?embiewska، نويسنده , , Edyta and Safranow، نويسنده , , Krzysztof and Bober، نويسنده , , Joanna and Doma?ski، نويسنده , , Leszek and R??a?ski، نويسنده , , Jacek and My?lak، نويسنده , , Marek، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Pages :
6
From page :
148
To page :
153
Abstract :
Background m of the study was to find the cause of decreased activity of extracellular superoxide dismutase (EC SOD) in patients with diabetes—is it the decreased synthesis or increased glycation? s EC SOD activity, the activity of its fractions (A, B, and C) and its glycated form were determined in basal state and 30 min after intravenous (i.v.) administration of 50 mg of heparin. Patients were given i.v. heparin at a dose of 10,000 IU (100 mg) each 6 h for at least 3 days, and the activity of EC SOD was determined before the first heparin administration, just before each subsequent administration, and 30 min after heparin administration. s nd postheparinic activities of EC SOD and its fraction C in the group of patients with diabetes were significantly lower (p <0.001) than in control group. Preheparinic activities of EC SOD did not differ between the examined groups of patients. The postheparinic activities were different during the first 18 h of treatment. They were significantly lower in the group of patients with diabetes. During the following hours, after subsequently administered doses, there were no differences in the activity of EC SOD between the examined groups. Decline of EC SOD activity was observed after administration of repeated doses of heparin both in the examined and in the control groups. sions crease of extracellular superoxide dismutase activity in diabetes develops due to excessive glycation but not due to impaired synthesis. Therefore, appropriate glycemic control can lead to normalization of EC SOD activity.
Keywords :
glycation , Superoxide Dismutase , HEPARIN , diabetes
Journal title :
Archives of Medical Research
Serial Year :
2005
Journal title :
Archives of Medical Research
Record number :
1795384
Link To Document :
بازگشت