Blood Coagulation Unaffected by Ozonated Autohemotherapy in Patients on Maintenance Hemodialysis

Background ed autohemotherapy (O3-AHT) is a clinically useful therapeutic procedure in hemodialyzed patients with peripheral arterial occlusive disease (PAOD). The majority of patients on dialysis are in a hypercoagulable state. Thrombotic complications are the major cause of morbidity and mortality in hemodialyzed patients. Effects of O3-AHT on blood coagulation were evaluated in 11 hemodialyzed patients affected by PAOD. s formed an oxygen-controlled, crossover study in which nine sessions of autohemotherapy with oxygen administration (AHT) as a control were followed by nine sessions of O3-AHT. Blood coagulation was assessed by antithrombin III, activated partial thromboplastin time, prothrombin time, D-dimer and fibrinogen plasma concentrations. s tents of all the measured parameters after nine sessions of O3-AHT did not differ statistically from the values after nine sessions of AHT. Similarly, there were no differences in the measured variables after the first session of O3-AHT as compared to the values before therapy. We did not observe any thrombotic accidents during the study. sions with ozone concentration of 50 μg/mL and citrate as an anticoagulant does not influence blood coagualation parameters in hemodialyzed patients with PAOD.