Preparations and properties of amino acid/dodecylamine/ibuprofen/H2O vesicles and microspheres

Stable vesicles and microspheres are directly prepared in amino acid/dodecylamine (DA)/ibuprofen/H2O system. Vesicle can be automatically formed in glycine/DA/H2O system. No vesicle and microsphere are found in l-glutamic acid or l-histidine/DA/H2O systems. When ibuprofen is added into amino acid/DA/H2O system, vesicles and microspheres can be formed and coexisted. Ibuprofen can regulate the quantity ratios between the vesicles and the microspheres. The structure properties of amino acid affect on the stabilities of the vesicles and microspheres. The formation mechanisms of the vesicles and microspheres are also discussed in this paper.