Author/Authors :
Okano، نويسنده , , Masayoshi and Fukamiya، نويسنده , , Narihiko and Tagahara، نويسنده , , Kiyoshi and Tokuda، نويسنده , , Harukuni and Iwashima، نويسنده , , Akio and Nishino، نويسنده , , Hoyoku and Lee، نويسنده , , Kuo-Hsiung، نويسنده ,
Abstract :
Short-term in vitro assays for tumor promoters and anti-tumor promoters (Epstein-Barr virus activation test) were carried out for 45 quassinoids. As a result, some quassinoids showed potent activity, more than 50% inhibition at a molar ratio of 1:1 (TPA/quassinoids). These results led to the following structure-activity relationships: (1) a methyleneoxy bridge and side chain enhance the activity and (2) a sugar moiety reduces the activity.
Keywords :
Anti-tumor promoting effect , Epstein-Barr virus activation test , quassinoids , structure-activity relationships
