Author/Authors :
Takada، نويسنده , , Nobuyasu and Yano، نويسنده , , Yoshihisa and Matsuda، نويسنده , , Tsutomu and Otani، نويسنده , , Shuzo and Osugi، نويسنده , , Harushi and Higashino، نويسنده , , Masayuki and Kinoshita، نويسنده , , Hiroaki and Fukushima، نويسنده , , Shoji، نويسنده ,
Abstract :
Hepatocyte growth factor (HGF) is a potent mitogen for epithelial cells that promotes cell motility and invasiveness. In this study, we report that the human esophageal squamous cell carcinoma (SCC) shows a significant elevation of HGF concentration (600 ± 416 ng/100 mg protein), compared to normal mucosa (80 ± 183 ng/100 mg protein) (P < 0.01). An association could be established between levels of HGF and decreasing differentiation of 37 SCCs. The 2-year crude survival rates were 51.1% and 68.4% at high and low HGF concentrations, respectively. The results indicate that HGF is significantly increased in human esophageal SCCs, especially of poorly differentiated type. HGF might thus be useful as a biological biomarker for characterization of human esophageal SCCs.
