Title of article
Alveolar stem cells in canine bronchial carcinogenesis
Author/Authors
Have-Opbroek، نويسنده , , A.A.W.Ten and Benfield، نويسنده , , J.R. and Hammond، نويسنده , , W.G. and Dijkman، نويسنده , , J.H.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
7
From page
211
To page
217
Abstract
Alveolar type II cells are not present in normal epithelium of canine segmentai bronchi but after carcinogen exposure they do occur in intra-epithelial lesions with all degrees of atypia and in invasive lesions with different glandular growth patterns. Immunohistochemistry for proliferation markers (PCNA; Ki-67) strongly suggest that such novel type II cells are pluripotential stem cells in canine bronchial carcinogenesis. Very likely, bronchial carcinogenesis is subject to an oncofetal mechanism of differentiation: bronchial epithelial retrodifferentiation followed by novel differentiation of alveolar tumor stem cells.
Keywords
Bronchial carcinogenesis , Nonsmall cell lung cancer , Stem (progenitor) cells , Breast/prostate carcinoma , proliferating cell nuclear antigen , alveolar type II cells
Journal title
Cancer Letters
Serial Year
1996
Journal title
Cancer Letters
Record number
1797188
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