Author/Authors :
Gunji، نويسنده , , Yoshio and Tagawa، نويسنده , , Masatoshi and Matsubara، نويسنده , , Hisahiro and Takenaga، نويسنده , , Keizo and Shimada، نويسنده , , Hideaki and Kondo، نويسنده , , Fukuo and Suzuki، نويسنده , , Takao and Nakajima، نويسنده , , Kazuaki and Sugaya، نويسنده , , Makoto and Asano، نويسنده , , Takehide and Ochiai، نويسنده , , Takenori and Isono، نويسنده , , Kaichi and Horitsu، نويسنده , , Keisuke and Kageyama، نويسنده , , Hajime and Nakamura، نويسنده , , Yohko and Sakiyama، نويسنده , , Shigeru، نويسنده ,
Abstract :
Murine colon carcinoma cells which secrete several kinds of cytokine after retroviral transduction with corresponding genes, were examined for their antitumor effects in syngeneic mice. The mice inoculated with granulocyte macrophage colony stimulating factor (GM-CSF) producer cells showed not only prolonged survival but also reduced tumorigenicity. The antitumor effect caused by the expression of interleukin-4 was less than that of GM-CSF, and interleukin-6 producer cells did not show any effects on the survival of the host animals. Histological examination of the GM-CSF-producing tumor revealed predominant infiltration of neutrophils and necrotic change of the tumor. The present study indicates the feasibility of cancer gene therapy with the expression of GM-CSF gene in tumor cells.
