Title of article
Inhibition of mucosal lipid hyperoxidation by green tea extract in 1,2-dimethylhydrazine-induced rat colonic carcinogenesis
Author/Authors
Matsumoto، نويسنده , , Hirohiko and Yamane، نويسنده , , Tetsuro and Inagake، نويسنده , , Masao and Nakatani، نويسنده , , Hirohisa and Iwata، نويسنده , , Yasushi and Takahashi، نويسنده , , Toshio and Nishimura، نويسنده , , Hiroshi and Nishino، نويسنده , , Hoyoku and Nakagawa، نويسنده , , Kiyotaka and Miyazawa، نويسنده , , Teruo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
5
From page
205
To page
209
Abstract
Phosphatidylcholine hydroperoxide (PCOOH) measured using a chemiluminescence detector to examine colonic mucosal lipid hyperoxidation increased after injection of 1,2-dimethylhydrazine and green tea extract (GTE), which we previously showed inhibited carcinogenesis and oxidative DNA damage in the gastrointestinal tract. Therefore, the hyperoxidation of membrane phospholipids reflected well the degree of DNA damage and carcinogenic alteration, and may be a useful intermediate biomarker for initiation of carcinogenesis.
Keywords
Green Tea Extract , Chemiluminescence , 2-Dimethylhydrazine , 1 , Intermediate biomarker , Phosphatidylcholine hydroperoxide
Journal title
Cancer Letters
Serial Year
1996
Journal title
Cancer Letters
Record number
1797319
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