Author/Authors :
Matsumoto، نويسنده , , Hirohiko and Yamane، نويسنده , , Tetsuro and Inagake، نويسنده , , Masao and Nakatani، نويسنده , , Hirohisa and Iwata، نويسنده , , Yasushi and Takahashi، نويسنده , , Toshio and Nishimura، نويسنده , , Hiroshi and Nishino، نويسنده , , Hoyoku and Nakagawa، نويسنده , , Kiyotaka and Miyazawa، نويسنده , , Teruo، نويسنده ,
Abstract :
Phosphatidylcholine hydroperoxide (PCOOH) measured using a chemiluminescence detector to examine colonic mucosal lipid hyperoxidation increased after injection of 1,2-dimethylhydrazine and green tea extract (GTE), which we previously showed inhibited carcinogenesis and oxidative DNA damage in the gastrointestinal tract. Therefore, the hyperoxidation of membrane phospholipids reflected well the degree of DNA damage and carcinogenic alteration, and may be a useful intermediate biomarker for initiation of carcinogenesis.
Keywords :
Green Tea Extract , Chemiluminescence , 2-Dimethylhydrazine , 1 , Intermediate biomarker , Phosphatidylcholine hydroperoxide
