Author/Authors :
Ishikawa، نويسنده , , Takashi and Ichikawa، نويسنده , , Yasushi and Mitsuhashi، نويسنده , , Masato and Momiyama، نويسنده , , Nobuyoshi and Chishima، نويسنده , , Takashi and Tanaka، نويسنده , , Kuniya and Yamaoka، نويسنده , , Hiroyuki and Miyazakic، نويسنده , , Kaoru and Nagashima، نويسنده , , Yoji and Akitaya، نويسنده , , Tatsuo and Shimada، نويسنده , , Hiroshi، نويسنده ,
Abstract :
Matrilysin and gelatinase A, B mRNA expressions were examined in colorectal tumors. Matrilysin mRNA was observed exclusively in tumors, while the others were also found in normal mucosa surrounding tumors. Further analysis revealed that colorectal adenomas with severe dysplasia, not with mild dysplasia, expressed matrilysin with lower levels than cancers. The level of matrilysin mRNA expression increased with the advancement of stages of colorectal cancers, consequently a relatively higher expression was observed in liver metastatic tumors than primary tumors. These results suggest that matrilysin mRNA expression was correlated with the progression of colorectal tumors, and this enzyme may also play a role in developing metastatic tumors in liver.
Keywords :
Gelatinase-B , Gelatinase-A , Colorectal tumor , matrilysin
