Meta-Analysis of MMP2 –1306T Allele as a Protective Factor in Digestive Cancer

Background and Aims metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity on matrix proteins and abolishes a Sp-1 binding site and consequently decreases its activity. Many studies have been carried out on the association between MMP2 –1306C/T polymorphism and digestive cancer risk, but results were somewhat controversial and underpowered. s mine the risk of digestive cancer associated with –1306C/T polymorphism of MMP2, we performed a meta-analysis of ten case-control studies. Eligible studies were identified by searching the electronic literature using Pubmed and Embase. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. s l, we found that –1306T allele can decrease digestive cancer risk in three different genotype models (T-allele vs. C-allele, OR = 0.73, 95% CI: 0.54–0.98, p = 0.034; TC vs. CC, OR = 0.64, 95% CI: 0.53–0.78, p <0.001; TT+TC vs. CC, OR = 0.68, 95% CI: 0.53–0.86, p = 0.002). Similarly, in the stratified analysis by cancer type, ethnicity and source of control, significantly decreased cancer risk was indicated. Moreover, in the subgroup of smokers, –1306T allele may protect people against digestive cancer risk (TT+TC vs. CC, OR = 0.71, 95% CI: 0.51–0.98, p = 0.037). sions ta-analysis showed evidence that MMP2 –1306T allele may be a protective factor for digestive cancer risk as well as a low-penetrance susceptibility digestive cancer biomarker.