Relation of HLA-A, -B, -DRB1 Alleles and Haplotypes in Patients with Acute Leukemia: A Case Control Study

Background and Aims tionship between acute leukemia and HLA alleles has been demonstrated in several studies. However, the frequencies of HLA class I (A, B) and class II (DRB1) alleles and haplotypes has not already been determined in Turkish patients with acute leukemia. s estigated the relation of the HLA alleles and haplotypes in 237 adult acute leukemia patients [103 acute lymphoblastic leukemia (ALL), 134 acute myeloid leukemia, (AML)] and 360 unrelated normal subjects by PCR-SSOP method using Luminex technology. s frequencies of HLA-A∗03, and B∗51 were higher in patients with AML compared with the controls (p = 0.019, and p = 0.001; respectively). Furthermore, HLA-A∗11 and DRB1∗01 allele frequencies were determined to be higher in patients with ALL (p = 0.01, p = 0.001; respectively), whereas DRB1∗13 allele frequencies lower than controls (p = 0.003). The most observed haplotypes A∗03 B∗51 DRB1∗11 (3.73 vs. 0%) in patients with AML; A∗02 B∗35 DRB1∗01 (2.91 vs. 0%) and A∗02 B∗51 DRB1∗11 (2.91 vs. 1.96%) in patients with ALL were determined. On the contrary, the most observed haplotype was A∗02 B∗35 DRB1∗13 (2.19%) in the controls. We found A∗02 B∗39 DRB1∗16 haplotype negatively associated with AML, whereas A∗02 B∗35 DRB1∗13 was in ALL (p = 0.015, and p = 0.017; respectively). sions results suggest that HLA-A∗03 and B∗51 alleles may play a presumptive predisposing factor in AML. In addition, HLA-A∗11 and DRB∗01 alleles have been found to be associated with ALL, whereas DRB1∗13 allele was determined to be negatively associated.