Author/Authors :
Fujita، نويسنده , , Masayuki and Takahashi، نويسنده , , Rei and Kitada، نويسنده , , Kazuhiro and Watanabe، نويسنده , , Rei and Kitazawa، نويسنده , , Sohei and Ashoori، نويسنده , , Faramarz and Liang، نويسنده , , Ping and Saya، نويسنده , , Hideyuki and Serikawa، نويسنده , , Tadao and Maeda، نويسنده , , Sakan، نويسنده ,
Abstract :
An alternative splicing of the rat erythropoietin receptor (EpoR) gene was identified in normal and erythroleukemia cells. A 105 bp insert was found at a region corresponding to the extracellular domain of EpoR. The alternative transcript was translated to a soluble EpoR (EpoR-S) expressed in spleen, bone marrow, and cultured erythroleukemia cells in addition to the full-length EpoR (EpoR-F). One of the rat erythroleukemia sublines, K4DT, which partially lost erythroid phenotypes and manifested monocyte/macrophage characteristics also lacked EpoR-S expression. Thus, expression of EpoR-S may play an important role in differentiation of rat erythroid cells.
