Interleukin-6 Polymorphisms Are Associated with Obesity and Hyperglycemia in Mexican Adolescents

Background and Aims eukin-6 is an inflammatory response mediator used as a metabolic marker of obesity. Polymorphisms IL6 −597C>A, −572G>C, and −174G>C modify the production of this protein. The associations between these haplotypes and obesity or metabolic markers have not been studied in adolescents, so an analysis of these associations was performed. s oss-sectional study included 745 apparently healthy 14- to 19-year-old adolescents. Obesity, serum glucose, insulin, triglycerides, total cholesterol, low-density lipoprotein–cholesterol, high-density lipoprotein–cholesterol (HDL-C), and high-sensitivity C-reactive protein (hs-CRP) were evaluated, and IL6 −597G>A, −572G>C and −174G>C polymorphisms determined. The associations were analyzed using multivariate logistic regression models. s lele frequencies were 0.15 for −597A and −174C and 0.30 for −572C. Genotypes were in Hardy–Weinberg equilibrium. IL-6−597/−572/−174 haplotypes GGG, GCG, and AGC comprised 99.74% of the total haplotypes. The associations were significant between genotype GCG/GCG and hyperglycemia (OR = 2.86, 95% CI = 1.02–7.97); between GCG/GCG and high hs-CRP (OR = 6.17, 95% CI = 1.13–33.77); between AGC/AGC and obesity (OR = 4.42, 95% CI = 1.40–14.01); and between GGG/GCG and low HDL-C (OR = 1.53, 95% CI = 1.03–2.28). sions pes of the IL6−597/−572/−174 polymorphisms are associated with metabolic risk factors in Mexican adolescents.