Author/Authors :
Carbَ، نويسنده , , Neus and Lَpez-Soriano، نويسنده , , Joaquيn and Tarragَ، نويسنده , , M. Teresa and Gonzلlez-Sanjosé، نويسنده , , Olga and Llovera، نويسنده , , Marta and Lَpez-Soriano، نويسنده , , Francisco J. and Argilés، نويسنده , , Josep M.، نويسنده ,
Abstract :
The implantation of the Yoshida AH-130 ascites hepatoma (a fast growing tumour) to rats resulted in a dramatic loss of both white adipose tissue and muscle (skeletal and cardiac) mass. Administration of β2-adrenergic agonists to tumour-bearing rats resulted in a partial recovery of skeletal muscle and heart mass. Treatment of the tumour-bearing animals with the different drugs (salbutamol, salmeterol and clenbuterol) did not influence tumour growth or food intake so it can be suggested that the effects were solely due to metabolic changes. In addition, while the three drugs had clear effects on gastrocnemius muscles, clenbuterol and salbutamol had also an effect on soleus, and salbutamol had a clear effect on cardiac muscle, It is saggested that any of the studied β2-adrenergic agonists (but perhaps, particularly salmeterol) could be used clinically in the treatment of cancer cachexia.
