Author/Authors :
Vennegoor، نويسنده , , Claus J.G.M and Nijman، نويسنده , , Hans W and Drijfhout، نويسنده , , Jan Wouter and Vernie، نويسنده , , Leen and Verstraeten، نويسنده , , Rob A and von Mensdorff-Pouilly، نويسنده , , Silvia and Hilgers، نويسنده , , Jo and Verheijen، نويسنده , , René H.M and Kast، نويسنده , , W.Martin and Melief، نويسنده , , Cornelis J.M and Kenemans، نويسنده , , Peter، نويسنده ,
Abstract :
Autoantibodies against complete p53 protein and 18-mer peptides of p53 in ovarian cancer patients and healthy women were examined. Sera from 9% (4/46) of ovarian cancer patients but none (0/51) of healthy women recognized complete p53 protein. The antibodies were mainly of the IgG1 isotype. Two patients had also IgG2 antibodies. Sera from 28% (13/46) of cancer patients and 21% (11/52) of healthy women contained either IgM, or IgM plus IgG2 antibodies against 18-mer p53 peptides. Screening against complete p53 protein instead of peptides seems necessary for identifying patients with tumor-related antibodies. IgG2 antibodies against p53 suggest p53-specific CD4+ T helper 1 cell activity in some of the ovarian cancer patients.
Keywords :
p53 , Ovarian cancer , Tumor suppressor gene , autoantibodies , human
