Author/Authors :
Fukutome، نويسنده , , Kazuo and Watanabe، نويسنده , , Masatoshi and Shiraishi، نويسنده , , Taizo and Murata، نويسنده , , Mariko and Uemura، نويسنده , , Hiroji and Kubota، نويسنده , , Yoshinobu and Kawamura، نويسنده , , Juichi and Ito، نويسنده , , Haruo and Yatani، نويسنده , , Ryuichi، نويسنده ,
Abstract :
The potential involvement of N-acetyltransferase 1 (NAT1) genetic polymorphisms in prostate cancer (PCa) patients was analyzed in 101 patients with PCa and 97 controls with no incidental malignancy. Identification of NAT1*10, the variant allele associated with the rapid acetylator phenotype was by allele-specific polymerase chain reaction (PCR). When the NAT1*10 heterozygote and other genotypes without NAT1*10 allele were considered as low risk genotypes, NAT1*10/NAT1*10 had a significantly higher risk of PCa (OR=2.4, 95% CI; 1.0–5.6). If our preliminary results can be confirmed in a larger population, it may be a useful marker for PCa risk.
Keywords :
Risk analysis , N-acetyltransferase 1 , prostate cancer , Genetic poslymorphism
