Author/Authors :
Iwase ، نويسنده , , Yukiko and Takemura، نويسنده , , Yuko and Ju-ichi، نويسنده , , Motoharu and Kawaii، نويسنده , , Satoru and Yano، نويسنده , , Masamichi and Okuda، نويسنده , , Yoko and Mukainaka، نويسنده , , Teruo and Tsuruta، نويسنده , , Atsushi and Okuda، نويسنده , , Masato and Takayasu، نويسنده , , Junko and Tokuda، نويسنده , , Harukuni and Nishino، نويسنده , , Hoyoku، نويسنده ,
Abstract :
To search useful compounds in Citrus fruit for cancer chemoprevention, we carried out a primary screening of extracts of fruit peels and seeds from 78 species of the genus Citrus and those from two Fortunella and one Poncirus species, which were closely related to the genus Citrus. These Citrus extracts inhibited the Epstein–Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) as a useful screening method for anti-tumor promoters. Our results indicated that Citrus containing substances may be inhibit susceptibility factors involved in the events leading to the development of cancer.
Keywords :
citrus , Anti-tumor promoter , Epstein–Barr virus , cancer chemoprevention
