Author/Authors :
Mitsuhashi، نويسنده , , Norio and Islam، نويسنده , , Mohammad Shahidul and Sakurai، نويسنده , , Hideyuki and Takahashi، نويسنده , , Takeo and Murata، نويسنده , , Osamu and Maebayashi، نويسنده , , Katsuya and Nozaki، نويسنده , , Miwako and Akimoto، نويسنده , , Tetsuo and Muramatsu، نويسنده , , Hiroyuki and Niibe، نويسنده , , Hideo، نويسنده ,
Abstract :
The differences between two rat yolk sac tumor cell lines, which are of the same origin but differ in their response to irradiation, in thermal sensitivity and development of thermotolerance were investigated. A radiosensitive cell line NMT-1 is consistently less heat sensitive than the radioresistant cell line NMT-1R. The thermotolerances in NMT-1 and in NMT-1R preheated at 43°C for 30 min, respectively, reached peaks at 6 h and at 12 h, but did not completely disappear at 48 h. Thermotolerance with a good correlation between both cell lines with HSP70 accumulation was observed in a different time course after a primary heating.
Keywords :
Radiosensitivity , Thermosensitivity , hsp70 , Thermotolerance
