Title of article
The effect of 6-methylthiohexyl isothiocyanate isolated from Wasabia japonica (wasabi) on 4-(methylnitrosamino)-1-(3-pyridyl)-1-buatnone-induced lung tumorigenesis in mice
Author/Authors
Yano، نويسنده , , Tomohiro and Yajima، نويسنده , , Shoko and Virgona، نويسنده , , Nantiga and Yano، نويسنده , , Yoshihisa and Otani، نويسنده , , Shuzo and Kumagai، نويسنده , , Hiromi and Sakurai، نويسنده , , Hidetoshi and Kishimoto، نويسنده , , Mikako and Ichikawa، نويسنده , , Tomio، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
6
From page
115
To page
120
Abstract
The present study was undertaken to estimate the effect of 6-methylthiohexyl isothiocyanate (6MHITC) isolated from Wasabia japonica (wasabi) pretreatment on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone(NNK)-induced lung tumorigenesis in mice. Pretreatment with 6MHITC for 4 consecutive days at a daily dose of 5 μmol significantly inhibited NNK-induced O6-methylguanine formation in lungs at 4 h after the injection. In conjugation with this inhibitory effect, 6MHITC suppressed the increase in proliferating nuclear cell antigen level as well as ornithine decarboxylase activity at a promotion stage of NNK-induced lung tumorigenesis. Finally, this treatment of 6MHITC suppressed the NNK-induced lung tumorigenesis in mice. These results suggest that 6MHITC inhibits the development of lung tumors in mice treated with NNK, due to the suppression of initiation stage.
Keywords
ornithine decarboxylase , tumorigenesis , proliferating cell nuclear antigen , 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone , Lung , 6-Methylhexylisothiocyanate
Journal title
Cancer Letters
Serial Year
2000
Journal title
Cancer Letters
Record number
1801459
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