Title of article
Conventional tumor markers are prognostic indicators in patients with head and neck squamous cell carcinoma
Author/Authors
Kimura، نويسنده , , Yuichi and Fujieda، نويسنده , , Shigeharu and Takabayashi، نويسنده , , Tetsuji and Tanaka، نويسنده , , Takeshi and Sugimoto، نويسنده , , Chizuru and Saito، نويسنده , , Hitoshi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
6
From page
163
To page
168
Abstract
We tested for squamous cell carcinoma-related antigen (SCC), carcinoembryonic antigen (CEA), ferritin, immunosuppressive acid protein (IAP) and sialic acid in the serum from 247 patients with head and neck squamous cell carcinoma prior to therapy. Significant correlations were found between IAP and tumor size, lymph node metastasis, and clinical stage (P<0.0001, P<0.001, and P<0.0001). Also, sialic acid and SCC were also correlated with tumor size, lymph node metastasis, and clinical stage. Moreover IAP, sialic acid and SCC were strongly associated with survival rate (P<0.0001, P=0.0230 and P=0.0159). A multivariate Cox proportional hazard model demonstrated that being positive for IAP was an independent predictor for patients with H&NSCC (P=0.0115). The results indicate that IAP, sialic acid and SCC are useful as prognostic factors.
Keywords
Sialic acid , Head and neck cancer , Immunosuppressive acid protein , Tumor Marker , Prognosis , Squamous cell carcinoma-related antigen
Journal title
Cancer Letters
Serial Year
2000
Journal title
Cancer Letters
Record number
1801486
Link To Document